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Polynucleotides Filler? Debunking the Myth

Updated: Sep 29, 2025

Polynucleotides, the fundamental building blocks of DNA and RNA, have long been a subject of fascination and inquiry in molecular biology. However, there persists a misconception surrounding their role. To understand their true significance and move beyond the idea that they are merely passive components in biological processes, it’s important to look at how polynucleotides function.


These molecules consist of chains of nucleotides, each comprising a phosphate group, a sugar molecule (deoxyribose in DNA or ribose in RNA), and a nitrogenous base (adenine, thymine, cytosine, and guanine in DNA; adenine, uracil, cytosine, and guanine in RNA). This arrangement forms the intricate double helix structure of DNA or the single-stranded configuration of RNA.


In aesthetic practice, polynucleotides are recognised for their ability to support cellular repair and regeneration, playing a vital role in maintaining skin elasticity, hydration, and overall quality. Free from components that can trigger an immune response, they work in harmony with the body’s own processes to help restore firmness and resilience while protecting against free radicals and cellular stress.

Far from being passive, polynucleotides serve a multitude of critical functions. Here are some of the key roles they play:


  • Stimulation of Collagen and Elastin: Polynucleotides stimulate the body’s natural production of collagen and elastin, proteins crucial for skin structure and elasticity. As collagen provides firmness and elastin contributes to elasticity, their decline with age leads to wrinkles and skin sagging. Polynucleotides counteract this process by promoting the synthesis of these vital proteins.

  • Enhanced Skin Hydration and Texture: Polynucleotides elevate skin hydration levels and texture by enhancing moisture retention, resulting in a more supple and plump appearance.

  • Promotion of Cellular Regeneration: Polynucleotides effectively promote the repair and renewal of skin cells, particularly beneficial for skin affected by environmental factors. This aids in reducing visible signs of ageing accelerated by external stressors.

  • Harmony with Natural Skin Processes: Polynucleotides work with the body’s natural processes, ensuring improvements that look and feel natural — something highly valued in modern aesthetics.


In light of these essential functions, it is evident that polynucleotides differ significantly from traditional HA fillers.


Whilst traditional HA fillers primarily focus on restoring volume to the skin in specific areas, polynucleotides offer additional benefits beyond contouring or volumising. These include improvements in skin texture, elasticity, and overall skin vitality.

To learn more about polynucleotide treatments, reach out to our team directly.








 
 
 

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