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Polynucleotides Filler? Debunking the Myth

Polynucleotides, the fundamental building blocks of DNA and RNA, have long been a subject of fascination and inquiry in the realm of molecular biology. However, there persists a misconception surrounding their role. To delve into the true significance of polynucleotides and debunk the notion that they are merely passive components in biological processes, let's first start with the competition of polynucleotides.


These molecules consist of chains of nucleotides, each comprising a phosphate group, a sugar molecule (deoxyribose in DNA or ribose in RNA), and a nitrogenous base (adenine, thymine, cytosine, and guanine in DNA; adenine, uracil, cytosine, and guanine in RNA). This arrangement forms the intricate double helix structure of DNA or the single-stranded configuration of RNA.

Ameela’s innovative aesthetic solution, offering a viscoelastic, sterile, non-pyrogenic, and absorbable formulation based on purified polymerised polynucleotides. These essential building blocks of DNA and RNA are crucial for cellular repair and regeneration, playing a vital role in maintaining skin elasticity, hydration, and overall quality. Free from components like proteins that can trigger an immune response, Ameela effectively restores skin firmness and elasticity while protecting against free radicals and cellular damage.  

Far from being passive aesthetic treatment, Ameela polynucleotides serve a multitude of critical functions. Here are some key roles they play:

Stimulation of Collagen and Elastin: Polynucleotides stimulate the body’s natural production of collagen and elastin, proteins crucial for skin structure and elasticity. As collagen provides firmness and elastin contributes to elasticity, their decline with age leads to wrinkles and skin sagging. Polynucleotides counteract this process by promoting the synthesis of these vital proteins.

Enhanced Skin Hydration and Texture: Polynucleotides elevate skin hydration levels and texture by enhancing moisture retention, resulting in a more supple and plump appearance.

Promotion of Cellular Regeneration: Polynucleotides effectively promote the repair and renewal of skin cells, particularly beneficial for skin damaged by environmental factors. This aids in mitigating the signs of ageing accelerated by external stressors.

Harmony with Natural Skin Processes: This treatment harmonises with the body’s innate skin processes, ensuring effective enhancements while maintaining a natural appearance - something that all aesthetic clients are looking to achieve. 

In light of these essential functions, it is evident that polynucleotides are very different to a traditional HA filler. 

Whilst traditional HA fillers primarily focus is to restore volume to the skin in specific areas, polynucleotides bring additional benefits beyond simply contouring or volumising the skin. These include potential effects on skin texture, elasticity, and overall skin rejuvenation

To learn more about polynucleotide fillers, reach out to the Ameela team directly. 


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