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Polynucleotides: What you need to know.


In the ever-evolving world of aesthetic medicine, the emergence of polynucleotides represents a significant leap forward. These biological polymers, foundational to the very structure of DNA, are now at the forefront of innovative skin rejuvenation treatments. Let's explore polynucleotides and what you need to know.

What are Polynucleotides?

Polynucleotides are large molecules made up of 13 or more nucleotide monomers linked in a chain. These nucleotides are the basic structural units of DNA and RNA, containing phosphate groups, sugars, and nitrogenous bases. But beyond their biological role, they possess intrinsic properties beneficial for skin health, including natural healing and regenerative capabilities.


The Role of Polynucleotides in Skin Health

The therapeutic potential of polynucleotides in aesthetic medicine lies in their ability to hydrate, repair, and protect the skin. When used in treatments, these molecules bind to water, enhancing skin hydration significantly. They also stimulate collagen production, which is vital for maintaining skin elasticity and firmness. Furthermore, their antioxidant properties help protect the skin from free radical damage, a key factor in premature ageing.


"Ameela has taken over 75% of our tear trough treatments because it not only gently fills instantly, it also has the long-term bio-stimulatory effects as well as an obvious brightening result which is exactly what most people want in the under eye region. We also see a lot of revisions and dissolving for tear trough filler because it is such a tricky area to fill and get right with dermal filler, whereas Ameela reacts to and stimulates your own tissue so it's much more natural and suitable for most delicate under eye areas and all of our Ameela patients seem to love their results."

Joelle Rotsaert, Injectual clinic

Polynucleotides vs. Traditional Treatments

Unlike traditional aesthetic treatments that often focus on masking symptoms or providing temporary solutions, polynucleotide treatments address underlying skin issues. They don’t just fill or stretch the skin; instead, they rejuvenate and revitalize it from within. This approach leads to more natural, longer-lasting results compared to some conventional methods.

Ameela®: A Benchmark in Polynucleotide Treatments

A standout example of polynucleotide application in aesthetic medicine is Ameela®, the first treatment of its kind on the market. Ameela® leverages the power of PDRN (polydeoxyribonucleotide), derived from salmon DNA, which is highly compatible with human DNA. This compatibility is key to its effectiveness and safety, ensuring the treatment is well-tolerated and free from adverse immune responses.

The Future is Here

The integration of polynucleotides in aesthetic treatments like Ameela® is just the beginning. As we continue to understand their full potential, these treatments are set to redefine skincare norms, offering more sustainable, effective, and holistic solutions for various skin concerns.

In conclusion, what do you need to know? Polynucleotides are not just another trend in the aesthetics industry; they are a scientific breakthrough with the potential to transform how we approach skin health and rejuvenation. They are another tool at the disposable of trained medical professionals and can be utilised for a number of different treatment indications, especially where traditional fillers may

If you want to learn more about how to apply polynucleotides in your practice speak to the team at Ameela and they will support you in getting started.


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