The hottest treatment of 2025
Polynucleotides are natural bio-stimulating molecules derived from DNA fragments that support skin repair, regeneration, and hydration. Acting as essential building blocks of healthy tissue, their unique molecular structure helps stimulate collagen and elastin production, improve elasticity, and protect against oxidative stress.
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By working at a cellular level, polynucleotides encourage natural renewal processes within the skin, leading to longer-lasting improvements in tone, texture, and overall vitality. Popular for their ability to deliver natural-looking results, they are increasingly recognised as one of the most effective treatments for restoring skin health and slowing visible signs of ageing.
What are Polynucleotides?
The basic unit of a nucleotide is formed by a 5-carbon ring ribose (deoxyribose) and aldose, and a nitrogen base attached to the C1 position on aldose. (An aldose is monosaccharide – a simple sugar).
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The nucleotides are formed by ester compounds with inorganic phosphate to C5 on aldose (the 5th carbon in the ring) Nucleotides are the monomeric units of nucleic acids.Different nucleotides react with carbohydrates, phosphate and nitrogen to give the nucleic acids, which is the large molecules called biopolymers.
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The most common nucleotides are DNA and RNA.
The cellular response
When applied to the skin, polynucleotides act as biological messengers, signalling to cells to increase their metabolic activity. This heightened cellular activity contributes to the regeneration of skin tissues, promoting a more youthful and vibrant complexion. Polynucleotides combat inflammation by modulating the immune response at the cellular level. This not only addresses existing inflammation but also prevents its recurrence, fostering an environment conducive to optimal skin health.
How do Polynucleotides work?
Polynucleotides work to prolong the activity of hyaluronic acid which is naturally occurring in the skin, and reduce its degradation by around 40%.
Injections of polynucleotides may be used in combination with hyaluronic acid-based fillers to create complimentary results based on different treatment and patient indications. Like many aesthetic medicine treatments available today, polynucleotides have a long track record in other medicinal fields long before their introduction to aesthetics.
Studies and publications have supported physician testimonials as evidence for polynucleotides regenerative results and staying power.
One of the most obvious benefits of an aesthetic treatment with polynucleotides is the likelihood of tangible results in areas which have historically been difficult to treat, or would require multiple products to achieve the desired result.
